The Pig: A Relevant Model for Evaluating the Neutrophil Serine Protease Activities during Acute Pseudomonas aeruginosa Lung Infection

Chevaleyre, Claire; Riou, Mickaël; Bréa, Déborah; Vandebrouck, Clarisse; Barc, Céline; Pezant, Jérémy; Melo, Sandrine; Olivier, Michel; Delaunay, Rémy; Boulesteix, Olivier; Berthon, Patricia; Rossignol, Christelle; Burlaud‐Gaillard, Julien; Becq, Frédéric; Gauthier, Francis; Si‐Tahar, Mustapha; Meurens, François; Berri, Mustapha; Caballero, Ignacio; Attucci, Sylvie

doi:10.1371/journal.pone.0168577

Public

The Pig: A Relevant Model for Evaluating the Neutrophil Serine Protease Activities during Acute Pseudomonas aeruginosa Lung Infection

Published in PLoS ONE • Dec 16, 2016

Authors:

Claire Chevaleyre

Mickaël Riou

Déborah Bréa

Abstract

The main features of lung infection and inflammation are a massive recruitment of neutrophils and the subsequent release of neutrophil serine proteases (NSPs). Anti-infectious and/or anti-inflammatory treatments must be tested on a suitable animal model. Mice models do not replicate several aspects ...

Subject

Proteases

Bronchoalveolar lavage

Pseudomonas aeruginosa

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