Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer

Pearlman, Rachel; L. Frankel, Wendy; Swanson, Benjamin; Zhao, Weiqiang; Yılmaz, Ahmet; S. Miller, Kristin; Bacher, Jason; Bigley, Christopher; Nelsen, Lori; J. Goodfellow, Paul; M. Goldberg, Richard; D. Paskett, Electra; G. Shields, Peter; L. Freudenheim, Jo; P. Stanich, Peter; Lattimer, Ilene; Arnold, Mark; Liyanarachchi, Sandya; F. Kalady, Matthew; Heald, Brandie; Greenwood, Carla; M. Paquette, Ian; Prues, Marla; J. Draper, David; Lindeman, Carolyn; Philip Kuebler, J.; A. Reynolds, Kelly; M. Brell, Joanna; A. Shaper, Amy; Mahesh, Sameer; Buie, Nicole; Weeman, Kisa; Shine, Kristin; Haut, Mitchell; E. Edwards, Joan; Bastola, Shyamal; Wickham, Karen; S. Khanduja, K.; Zacks, Rosemary; C. Pritchard, Colin; H. Shirts, Brian; Jacobson, Angela; Allen, Brian; de la Chapelle, Albert; Hampel, Heather; the Ohio Colorectal Cancer Prevention Initiative Study Group, for

doi:10.1001/jamaoncol.2016.5194

Public

Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer

Published in JAMA Oncology • Dec 19, 2016

Authors:

Rachel Pearlman

Wendy L. Frankel

Benjamin Swanson

Abstract

IMPORTANCE: Hereditary cancer syndromes infer high cancer risks and require intensive cancer surveillance, yet the prevalence and spectrum of these conditions among unselected patients with early-onset colorectal cancer (CRC) is largely undetermined. OBJECTIVE: To determine the frequency and spectru...

Subject

Medicine

PMS2

Lynch syndrome

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