Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity

Soethoudt, Marjolein; Grether, Uwe; Fingerle, Jürgen; W. Grim, Travis; Fezza, Filomena; de Petrocellis, Luciano; Ullmer, Christoph; Rothenhäusler, Benno; Perret, Camille; van Gils, Noortje; Finlay, David; MacDonald, Christa; Chicca, Andrea; Dalghi Gens, Marianela; Stuart, Jordyn; de Vries, Henk; Mastrangelo, Nicolina; Xia, Lizi; Alachouzos, Georgios; P. Baggelaar, Marc; Martella, Andrea; D. Mock, Elliot; Deng, Hui; H. Heitman, Laura; Connor, Mark; Di Marzo, Vincenzo; Gertsch, Jürg; H. Lichtman, Aron; Maccarrone, Mauro; Pacher, Pal; Glass, Michelle; van der Stelt, Mario

doi:10.1038/ncomms13958

Public

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity

Shared by NobleBlocks on Jan 3, 2017 • 12:00 AM UTC

Authors:

Marjolein Soethoudt

Uwe Grether

Jürgen Fingerle

Abstract

Abstract The cannabinoid CB 2 receptor (CB 2 R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB 2 R, their selectivity, molecular mode of action and pharmacokinetic pr...

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