Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent

Rajakrishnan, R.; Lekshmi, R.; Benil, P.B.; Thomas, Jacob; Alfarhan, Ahmed; Rakesh, V.; M H Khalaf, Sameh

doi:10.1016/j.sjbs.2017.01.001

Public

Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent

Published in Saudi Journal of Biological Sciences • Jan 8, 2017

Authors:

R. Rajakrishnan

R. Lekshmi

P.B. Benil

Abstract

(HAPZ) in cisplatin induced nephrotoxicity was analyzed in Swiss albino mice. Treatment with higher dose (400 mg/kg) of HAPZ significantly reversed the adverse effect of cisplatin on kidney weight, serum urea and creatinine, indicating their renoprotective effect. The antioxidant effect of the drug ...

Subject

Phytochemical

Nephrotoxicity

Traditional medicine

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