The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal‐to‐zygotic transition

Yang, Ye; Zhou, Cheng; Wang, Ying; Liu, Weixiao; Liu, Chao; Wang, Liying; Liu, Yujiao; Shang, Yongliang; Li, Mingrui; Zhou, Shuai; Wang, Yuanting; Zeng, Wentao; Zhou, Jianli; Huo, Ran; Li, Wei

doi:10.15252/embr.201642573

Public

The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal‐to‐zygotic transition

Published in EMBO Reports • Jan 10, 2017

Authors:

Ye Yang

Cheng Zhou

Ying Wang

Abstract

The functional role of the ubiquitin‐proteasome pathway during maternal‐to‐zygotic transition (MZT) remains to be elucidated. Here we show that the E3 ubiquitin ligase, Rnf114, is highly expressed in mouse oocytes and that knockdown of Rnf114 inhibits development beyond the two‐cell stage. To study ...

Subject

China

Stem cell biology

Beijing

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