Macrophage-Derived mir-155-Containing Exosomes Suppress Fibroblast Proliferation and Promote Fibroblast Inflammation during Cardiac Injury

Wang, Chunxiao; Zhang, Congcong; Liu, Luxin; A, Xi; Chen, Boya; Li, Yulin; Du, Jie

doi:10.1016/j.ymthe.2016.09.001

Public

Macrophage-Derived mir-155-Containing Exosomes Suppress Fibroblast Proliferation and Promote Fibroblast Inflammation during Cardiac Injury

Published in Molecular Therapy • Jan 1, 2017

Authors:

Chunxiao Wang

Congcong Zhang

Luxin Liu

Abstract

Inflammation plays an important role in cardiac injuries. Here, we examined the role of miRNA in regulating inflammation and cardiac injury during myocardial infarction. We showed that mir-155 expression was increased in the mouse heart after myocardial infarction. Upregulated mir-155 was primarily ...

Subject

Fibroblast

Microvesicles

Inflammation

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