Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

E. Askew, Katharine; Li, Kaizhen; Olmos‐Alonso, Adrián; García‐Moreno, Fernando; Liang, Yajie; Richardson, Philippa; Tipton, Tom; A. Chapman, Mark; Riecken, Kristoffer; Beccari, Sol; Sierra, Amanda; Molnár, Zoltán; S. Cragg, Mark; Garaschuk, Olga; Hugh Perry, V.; Gómez‐Nicola, Diego

doi:10.1016/j.celrep.2016.12.041

Public

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

Published in Cell Reports • Jan 1, 2017

Authors:

Katharine E. Askew

Kaizhen Li

Adrián Olmos‐Alonso

Abstract

Microglia play key roles in brain development, homeostasis, and function, and it is widely assumed that the adult population is long lived and maintained by self-renewal. However, the precise temporal and spatial dynamics of the microglial population are unknown. We show in mice and humans that the ...

Subject

Microglia

Neuroscience

Biology

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