One-Step Continuous Flow Synthesis of Antifungal WHO Essential Medicine Flucytosine Using Fluorine

Harsányi, Antal; Conté, Annelyse; Pichon, Laurent; Rabion, Alain; Grenier, Sandrine; Sandford, Graham

doi:10.1021/acs.oprd.6b00420

Public

One-Step Continuous Flow Synthesis of Antifungal WHO Essential Medicine Flucytosine Using Fluorine

Published in Organic Process Research & Development • Jan 5, 2017

Authors:

Antal Harsányi

Annelyse Conté

Laurent Pichon

Abstract

High Resolution Image Download MS PowerPoint Slide In Africa around 625 000 mortalities per annum (20% of HIV/AIDS related deaths) are due to the affects of the Cryptococcal meningitis (CM) fungal infection. Recently, the World Health Organisation (WHO) and the Infectious Disease Society of America ...

Subject

Flucytosine

Amphotericin B

Fluconazole

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