International, evidence-based consensus diagnostic criteria for HHV-8–negative/idiopathic multicentric Castleman disease

C. Fajgenbaum, David; S. Uldrick, Thomas; Bagg, Adam; Frank, Dale; Wu, David; Srkalovic, Gordan; Simpson, David; Y. Liu, Amy; Menke, David; Chandrakasan, Shanmuganathan; Jo Lechowicz, Mary; S. M. Wong, Raymond; Pierson, Sheila; Paessler, Michele; Rossi, Jean-François; Ide, Makoto; Ruth, Jason; Croglio, Michael; Suarez, Alexander; Krymskaya, Vera; Chadburn, Amy; Colleoni, Gisele; Nasta, Sunita; Jayanthan, Raj; S. Nabel, Christopher; Casper, Corey; Dispenzieri, Angela; Fosså, Alexander; Kelleher, Dermot; Kurzrock, Razelle; Voorhees, Peter; Dogan, Ahmet; Yoshizaki, Kazuyuki; van Rhee, Frits; Oksenhendler, Eric; S. Jaffe, Elaine; S. J. Elenitoba-Johnson, Kojo; S. Lim, Megan

doi:10.1182/blood-2016-10-746933

Public

International, evidence-based consensus diagnostic criteria for HHV-8–negative/idiopathic multicentric Castleman disease

Shared by NobleBlocks on Mar 23, 2017 • 12:00 AM UTC

Authors:

David C. Fajgenbaum

Thomas S. Uldrick

Adam Bagg

Abstract

Key Points An international panel established the first ever diagnostic criteria for iMCD based on review of 244 clinical cases and 88 tissue samples. The criteria require multicentric lymphadenopathy with defined histopathology, ≥2 clinical/laboratory changes, and exclusion of iMCD mimics.

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