Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis

M. Hoglund, Richard; Workman, Lesley; D. Edstein, Michael; Xuân Thành, Nguyễn; Ngoc Quang, Nguyen; Zongo, Issaka; Ouédraogo, Jean‐Bosco; Borrmann, Steffen; Mwai, Leah; Nsanzabana, Christian; N. Price, Ric; Dahal, Prabin; C. Sambol, Nancy; Parikh, Sunil; Nosten, François; A. Ashley, Elizabeth; Pyae Phyo, Aung; Maung Lwin, Khin; McGready, Rose; Day, Nicholas; J. Guérin, Philippe; J. White, Nicholas; I. Barnes, Karen; Tärning, Joel

doi:10.1371/journal.pmed.1002212

Public

Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis

Published in PLoS Medicine • Jan 10, 2017

Authors:

Richard M. Hoglund

Lesley Workman

Michael D. Edstein

Abstract

BACKGROUND: Artemisinin-based combination therapies (ACTs) are the mainstay of the current treatment of uncomplicated Plasmodium falciparum malaria, but ACT resistance is spreading across Southeast Asia. Dihydroartemisinin-piperaquine is one of the five ACTs currently recommended by the World Health...

Subject

Piperaquine

Medicine

Regimen

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