Discovery of Imidazo[1,2-<i>a</i>]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis

J. Tantry, Subramanyam; D. Markad, Shankar; Shinde, Vikas; Bhat, Jyothi; Balakrishnan, Gayathri; K. Gupta, Amit; Ambady, Anisha; Raichurkar, Anandkumar; Kedari, Chaitanyakumar; Sharma, Sreevalli; Vinay Mudugal, Naina; Narayan, Ashwini; N. Naveen Kumar, C.; Nanduri, Robert; Bharath, Sowmya; Reddy, Jitendar; Panduga, Vijender; Prabhakar, K; Kandaswamy, Karthikeyan; Saralaya, Ramanatha; Kaur, Parvinder; Dinesh, Neela; Guptha, Supreeth; Rich, Kirsty; Murray, David; Plant, Helen; Preston, Marian; Ashton, Helen; Plant, Darren; Walsh, Jarrod; J. Alcock, Peter; Naylor, Kathryn; Collier, Matthew; Whiteaker, James; E. McLaughlin, Robert; Mallya, Meenakshi; Panda, Manoranjan; Rudrapatna, Suresh; Ramachandran, Vasanthi; Krishan Shandil, Radha; K. Sambandamurthy, Vasan; Mdluli, Khisi; B. Cooper, Christopher; Rubin, Harvey; Yano, Takahiro; S. Iyer, Pravin; Narayanan, Shridhar; Kavanagh, Stefan; Mukherjee, Kakoli; Balasubramanian, V.; Hosagrahara, Vinayak; Solapure, Suresh; Ravishankar, Sudha; Hameed P, Shahul

doi:10.1021/acs.jmedchem.6b01358

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Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis

Published in Journal of Medicinal Chemistry • Jan 11, 2017

Authors:

Subramanyam J. Tantry

Shankar D. Markad

Vikas Shinde

Abstract

The approval of bedaquiline to treat tuberculosis has validated adenosine triphosphate (ATP) synthase as an attractive target to kill Mycobacterium tuberculosis (Mtb). Herein, we report the discovery of two diverse lead series imidazo[1,2-a]pyridine ethers (IPE) and squaramides (SQA) as inhibitors o...

Subject

Chemistry

Bedaquiline

ATP synthase

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