CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts

Tang, Chunmei; Zhang, Ming; Huang, Lei; Hu, Zhi-Qin; Zhu, Jie-Ning; Xiao, Zhen; Zhang, Zhuo; Lin, Qiu‐Xiong; Zheng, Xi‐Long; Yang, Min; Wu, Shulin; Cheng, Jianding; Shan, Zhi‐Xin

doi:10.1038/srep40342

Public

CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts

Published in Scientific Reports • Jan 12, 2017

Authors:

Chunmei Tang

Ming Zhang

Lei Huang

Abstract

Circular RNAs (circRNAs) participate in regulating gene expression in diverse biological and pathological processes. The present study aimed to investigate the mechanism underlying the modulation of circRNA_000203 on expressions of fibrosis-associated genes in cardiac fibroblasts. CircRNA_000203 was...

Subject

CTGF

Circular RNA

Downregulation and upregulation

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