Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance.

L Manson, Abigail; A Cohen, Keira; Abeel, Thomas; A Desjardins, Christopher; T Armstrong, Derek; E Barry, Clifton; Brand, Jeannette; Global Genome Consortium, TBResist; B Chapman, Sinéad; Cho, Sang-Nae; Gabrielian, Andrei; Gomez, James; M Jodals, Andreea; Joloba, Moses; Jureen, Pontus; Seok Lee, Jong; Malinga, Lesibana; Maiga, Mamoudou; Nordenberg, Dale; Noroc, Ecaterina; Romancenco, Elena; Salazar, Alex; Ssengooba, Willy; A Velayati, A; Winglee, Kathryn; Zalutskaya, Aksana; E Via, Laura; H Cassell, Gail; E Dorman, Susan; Ellner, Jerrold; Farnia, Parissa; E Galagan, James; Rosenthal, Alex; Crudu, Valeriu; Homorodean, Daniela; Hsueh, Po-Ren; Narayanan, Sujatha; S Pym, Alexander; Skrahina, Alena; Swaminathan, Soumya; Van der Walt, Martie; Alland, David; R Bishai, William; Cohen, Ted; Hoffner, Sven; W Birren, Bruce; M Earl, Ashlee

doi:10.1038/ng.3767

Public

Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance.

Shared by NobleBlocks on Mar 1, 2017 • 12:00 AM UTC

Authors:

Abigail L Manson

Keira A Cohen

Thomas Abeel

Abstract

Multidrug-resistant tuberculosis (MDR-TB), caused by drug-resistant strains of Mycobacterium tuberculosis, is an increasingly serious problem worldwide. Here we examined a data set of whole-genome sequences from 5,310 M. tuberculosis isolates from five continents. Despite the great diversity of thes...

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