Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance

L. Manson, Abigail; A. Cohen, Keira; Abeel, Thomas; A. Desjardins, Christopher; T. Armstrong, Derek; E. Barry, Clifton; Brand, Jeannette; B. Chapman, Sinéad; Cho, Sang-Nae; Gabrielian, Andrei; Gomez, James; M Jodals, Andreea; Joloba, Moses; Juréen, Pontus; Seok Lee, Jong; Anthony Malinga, Lesibana; Maïga, Mamoudou; Nordenberg, Dale; Noroc, Ecaterina; Romancenco, Elena; Salazar, Alex; Ssengooba, Willy; Akbar Velayati, Ali; Winglee, Kathryn; Zalutskaya, Aksana; E. Via, Laura; H. Cassell, Gail; E. Dorman, Susan; J. Ellner, Jerrold; Farnia, Parissa; E. Galagan, James; Rosenthal, Alex; Crudu, Valeriu; Homorodean, Daniela; Hsueh, Po‐Ren; Narayanan, Sujatha; S. Pym, Alexander; Skrahina, Alena; Swaminathan, Soumya; van der Walt, Martie; Alland, David; R. Bishai, William; Cohen, Ted; Hoffner, Sven; W. Birren, Bruce; M. Earl, Ashlee

doi:10.1038/ng.3767

Public

Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance

Published in Nature Genetics • Jan 16, 2017

Authors:

Abigail L. Manson

Keira A. Cohen

Thomas Abeel

Abstract

Ashlee Earl and colleagues analyze whole-genome sequences from 5,310 Mycobacterium tuberculosis isolates from five continents. They find that resistance to isoniazid arises before rifampicin resistance across all of the lineages, geographical regions and time periods. Multidrug-resistant tuberculosi...

Subject

Biology

Mycobacterium tuberculosis

Tuberculosis

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