Soluble Uric Acid Activates the NLRP3 Inflammasome

Teodoro Braga, Tárcio; Fernanda Forni, Maria; Corrêa-Costa, Matheus; Nalio Ramos, Rodrigo; Alexandre Marzagão Barbuto, José; Cristina Branco, Paola; Castoldi, Ângela; Ioshie Hiyane, Meire; Rodrigues Davanso, Mariana; Latz, Eicke; S. Franklin, Bernardo; J. Kowaltowski, Alicia; Olsen Saraiva Câmara, Niels

doi:10.1038/srep39884

Public

Soluble Uric Acid Activates the NLRP3 Inflammasome

Published in Scientific Reports • Jan 13, 2017

Authors:

Tárcio Teodoro Braga

Maria Fernanda Forni

Matheus Corrêa-Costa

Abstract

Abstract Uric acid is a damage-associated molecular pattern (DAMP), released from ischemic tissues and dying cells which, when crystalized, is able to activate the NLRP3 inflammasome. Soluble uric acid (sUA) is found in high concentrations in the serum of great apes, and even higher in some diseases...

Subject

Inflammasome

Uric acid

Chemistry

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