Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells

Lecendreux, Michel; Churlaud, Guillaume; Pitoiset, Fabien; Régnault, Armelle; Tran, Tú-Anh; Liblau, Roland; Klatzmann, David; Rosenzwajg, Michèlle

doi:10.1371/journal.pone.0169836

Public

Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells

Published in PLoS ONE • Jan 20, 2017

Authors:

Michel Lecendreux

Guillaume Churlaud

Fabien Pitoiset

Abstract

Narcolepsy is a rare neurologic disorder characterized by excessive daytime sleepiness, cataplexy and disturbed nocturnal sleep patterns. Narcolepsy type 1 (NT1) has been shown to result from a selective loss of hypothalamic hypocretin-secreting neurons with patients typically showing low CSF-hypocr...

Subject

Narcolepsy

Immunology

Immune system

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