Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon.

Sarah, Bettini,; Elisa, Boutet-Robinet,; Christel, Cartier,; Christine, Coméra,; Eric, Gaultier,; Jacques, Dupuy,; Nathalie, Naud,; Sylviane, Taché,; Patrick, Grysan,; Solenn, Reguer,; Nathalie, Thieriet,; Matthieu, Réfrégiers,; Dominique, Thiaudière,; Jean-Pierre, Cravedi,; Marie, Carrière,; Jean-Nicolas, Audinot,; Fabrice H, Pierre,; Laurence, Guzylack-Piriou,; Eric, Houdeau,

doi:10.1038/srep40373

Public

Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon.

Published in Scientific reports • Jan 20, 2017

Authors:

Bettini, Sarah

Boutet-Robinet, Elisa

Cartier, Christel

Abstract

Food-grade titanium dioxide (TiO2) containing a nanoscale particle fraction (TiO2-NPs) is approved as a white pigment (E171 in Europe) in common foodstuffs, including confectionary. There are growing concerns that daily oral TiO2-NP intake is associated with an increased risk of chronic intestinal i...

Subject

Administration

Oral

Animals

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