Testicular Dysgenesis Syndrome and Long-Lasting Epigenetic Silencing of Mouse Sperm Genes Involved in the Reproductive System after Prenatal Exposure to DEHP

Stenz, Ludwig; Escoffier, Jessica; Rahban, Rita; Nef, Serge; Paoloni‐Giacobino, Ariane

doi:10.1371/journal.pone.0170441

Public

Testicular Dysgenesis Syndrome and Long-Lasting Epigenetic Silencing of Mouse Sperm Genes Involved in the Reproductive System after Prenatal Exposure to DEHP

Published in PLoS ONE • Jan 13, 2017

Authors:

Ludwig Stenz

Jessica Escoffier

Rita Rahban

Abstract

The endocrine disruptor bis(2-ethylhexyl) phthalate (DEHP) has been shown to exert adverse effects on the male animal reproductive system. However, its mode of action is unclear and a systematic analysis of its molecular targets is needed. In the present study, we investigated the effects of prenata...

Subject

Biology

DNA methylation

Epigenetics

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