A computational psychiatry approach identifies how alpha-2A noradrenergic agonist Guanfacine affects feature-based reinforcement learning in the macaque

A. Hassani, Seyed; Oemisch, Mariann; Balcarras, Matthew; Westendorff, Stephanie; Ardid, Salva; A. A. van der Meer, Matthijs; Tiesinga, Paul; Womelsdorf, Thilo

doi:10.1038/srep40606

Public

A computational psychiatry approach identifies how alpha-2A noradrenergic agonist Guanfacine affects feature-based reinforcement learning in the macaque

Published in Scientific Reports • Jan 16, 2017

Authors:

Seyed A. Hassani

Mariann Oemisch

Matthew Balcarras

Abstract

Noradrenaline is believed to support cognitive flexibility through the alpha 2A noradrenergic receptor (a2A-NAR) acting in prefrontal cortex. Enhanced flexibility has been inferred from improved working memory with the a2A-NA agonist Guanfacine. But it has been unclear whether Guanfacine improves sp...

Subject

Guanfacine

Reinforcement learning

Cognitive flexibility

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