Hierarchical and Redundant Roles of Activating FcγRs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies

Van den Hoecke, Silvie; Ehrhardt, Katrin; Kolpe, Annasaheb; El Bakkouri, Karim; Deng, Lei; Grootaert, Hendrik; Schoonooghe, Steve; Smet, Anouk; Bentahir, Mostafa; Roose, Kenny; Schotsaert, Michael; Schepens, Bert; Callewaert, Nico; Nimmerjahn, Falk; Staeheli, Peter; Hengel, Hartmut; Saelens, Xavier

doi:10.1128/jvi.02500-16

Public

Hierarchical and Redundant Roles of Activating FcγRs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies

Published in Journal of Virology • Jan 12, 2017

Authors:

Silvie Van den Hoecke

Katrin Ehrhardt

Annasaheb Kolpe

Abstract

ABSTRACT The ectodomain of matrix protein 2 is a universal influenza A virus vaccine candidate that provides protection through antibody-dependent effector mechanisms. Here we compared the functional engagement of Fcγ receptor (FcγR) family members by two M2e-specific monoclonal antibodies (MAbs), M...

Subject

Ectodomain

Biology

Virology

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