Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells

Franzetti, G-A; Laud-Duval, Karine; van der Ent, Wietske; Brisac, AM; Irondelle, Marie; Aubert, Sébastien; Dirksen, Uta; Bouvier, Corinne; de Pinieux, Gonzague; Ewa Snaar‐Jagalska, B.; Chavrier, Philippe; Delattre, Olivier

doi:10.1038/onc.2016.498

Public

Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells

Published in Oncogene • Jan 30, 2017

Authors:

G-A Franzetti

Karine Laud-Duval

Wietske van der Ent

Abstract

Ewing sarcoma is characterized by the expression of the chimeric EWSR1-FLI1 transcription factor. Proteomic analyses indicate that the decrease of EWSR1-FLI1 expression leads to major changes in effectors of the dynamics of the actin cytoskeleton and the adhesion processes with a shift from cell-to-...

Subject

Biology

FLI1

Cell biology

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