Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

R. Warren, Helen; Εvangelou, Εvangelos; P. Cabrera, Claudia; Gao, He; Ren, Meixia; Mifsud, Borbála; Ntalla, Ioanna; Surendran, Praveen; Liu, Chunyu; P. Cook, James; T. Kraja, Aldi; Drenos, Fotios; Loh, Marie; Verweij, Niek; Marten, Jonathan; Karaman, İbrahim; P Segura Lepe, Marcelo; F. O’Reilly, Paul; Knight, Jo; Snieder, Harold; Kato, Norihiro; He, Jiang; Shyong Tai, E; Abdullah Said, M.; J. Porteous, David; Alver, Maris; R Poulter, Neil; Farrall, Martin; T. Gansevoort, Ron; Padmanabhan, Sandosh; Mägi, Reedik; Stanton, Alice; Connell, John; J. L. Bakker, Stephan; Metspalu, Andres; C. Shields, Denis; Thom, Simon; J. Brown, Morris; Sever, Peter; Esko, Tõnu; Hayward, Caroline; van der Harst, Pim; Saleheen, Danish; Chowdhury, Rajiv; C. Chambers, John; I. Chasman, Daniel; Chakravarti, Aravinda; Newton‐Cheh, Christopher; M. Lindgren, Cecilia; Levy, Daniel; S. Kooner, Jaspal; Keavney, Bernard; Tomaszewski, Maciej; J. Samani, Nilesh; M. M. Howson, Joanna; D. Tobin, Martin; B. Munroe, Patricia; Ehret, Georg; V. Wain, Louise; V Wain, Louise; Vaez, Ahmad; Jansen, Rick; Joehanes, Roby; J van der Most, Peter; Mesut Erzurumluoglu, A; O'Reilly, Paul; P Cabrera, Claudia; R Warren, Helen; M Rose, Lynda; C Verwoert, Germaine; Hottenga, Jouke-Jan; J Strawbridge, Rona; Esko, Tonu; E Arking, Dan; Hwang, Shih-Jen; Guo, Xiuqing; Kutalik, Zoltan; Trompet, Stella; Shrine, Nick; Teumer, Alexander; S Ried, Janina; C Bis, Joshua; V Smith, Albert; Amin, Najaf; M Nolte, Ilja; Lyytikäinen, Leo-Pekka; Mahajan, Anubha; J Wareham, Nicholas; Hofer, Edith; K Joshi, Peter; Kristiansson, Kati; Traglia, Michela; S Havulinna, Aki; Goel, Anuj; A Nalls, Mike; Sõber, Siim; Vuckovic, Dragana; Luan, Jian'an; Del Greco M, Fabiola; L Ayers, Kristin; Marrugat, Jaume; Ruggiero, Daniela; M Lopez, Lorna; Niiranen, Teemu; Enroth, Stefan; U Jackson, Anne; P Nelson, Christopher; E Huffman, Jennifer; Zhang, Weihua; Marten, Jonathan; Gandin, Ilaria; E Harris, Sarah; Zemonik, Tatijana; Lu, Yingchang; Evangelou, Evangelos; Shah, Nabi; H de Borst, Martin; Mangino, Massimo; P Prins, Bram; Campbell, Archie; Li-Gao, Ruifang; Chauhan, Ganesh; Oldmeadow, Christopher; Abecasis, Gonçalo; Abedi, Maryam; M Barbieri, Caterina; R Barnes, Michael; Batini, Chiara; Blake, Tineka; Boehnke, Michael; P Bottinger, Erwin; S Braund, Peter; Brown, Morris; Brumat, Marco; Campbell, Harry; C Chambers, John; Cocca, Massimiliano; Collins, Francis; Connell, John; J Cordell, Heather; J Damman, Jeffrey; Davies, Gail; J de Geus, Eco; de Mutsert, Renée; Deelen, Joris; Demirkale, Yusuf; S F Doney, Alex; Dörr, Marcus; Farrall, Martin; Ferreira, Teresa; Frånberg, Mattias; Gao, He; Giedraitis, Vilmantas; Gieger, Christian; Giulianini, Franco; J Gow, Alan; Hamsten, Anders; B Harris, Tamara; Hofman, Albert; G Holliday, Elizabeth; Jarvelin, Marjo-Riitta; Johansson, Åsa; D Johnson, Andrew; Jousilahti, Pekka; Jula, Antti; Kähönen, Mika; Kathiresan, Sekar; Khaw, Kay-Tee; Kolcic, Ivana; Koskinen, Seppo; Langenberg, Claudia; Larson, Marty; J Launer, Lenore; Lehne, Benjamin; C M Liewald, David; Cohort Study, Lifelines; Lin, Li; Lind, Lars; Mach, François; Mamasoula, Chrysovalanto; Menni, Cristina; Mifsud, Borbala; Milaneschi, Yuri; Morgan, Anna; D Morris, Andrew; C Morrison, Alanna; J Munson, Peter; Nandakumar, Priyanka; Tri Nguyen, Quang; Nutile, Teresa; J Oldehinkel, Albertine; A Oostra, Ben; Org, Elin; Padmanabhan, Sandosh; Palotie, Aarno; Paré, Guillaume; Pattie, Alison; W J H Penninx, Brenda; Poulter, Neil; P Pramstaller, Peter; T Raitakari, Olli; Ren, Meixia; Rice, Kenneth; M Ridker, Paul; Riese, Harriëtte; Ripatti, Samuli; Robino, Antonietta; I Rotter, Jerome; Rudan, Igor; Saba, Yasaman; Saint Pierre, Aude; F Sala, Cinzia; Sarin, Antti-Pekka; Schmidt, Reinhold; Scott, Rodney; A Seelen, Marc; C Shields, Denis; Siscovick, David; Sorice, Rossella; Stanton, Alice; J Stott, David; Sundström, Johan; Swertz, Morris; D Taylor, Kent; Thom, Simon; Tzoulaki, Ioanna; Tzourio, Christophe; G Uitterlinden, André; Society Scientific group, Understanding; Völker, Uwe; Vollenweider, Peter; Wild, Sarah; Willemsen, Gonneke; F Wright, Alan; Yao, Jie; Thériault, Sébastien; Conen, David; John, Attia; Sever, Peter; Debette, Stéphanie; O Mook-Kanamori, Dennis; Zeggini, Eleftheria; D Spector, Tim; van der Harst, Pim; N A Palmer, Colin; Vergnaud, Anne-Claire; J F Loos, Ruth; Polasek, Ozren; M Starr, John; Girotto, Giorgia; Hayward, Caroline; S Kooner, Jaspal; M Lindgren, Cecila; Vitart, Veronique; J Samani, Nilesh; Tuomilehto, Jaakko; Gyllensten, Ulf; Knekt, Paul; J Deary, Ian; Ciullo, Marina; Elosua, Roberto; D Keavney, Bernard; A Hicks, Andrew; A Scott, Robert; Gasparini, Paolo; Laan, Maris; Liu, YongMei; Watkins, Hugh; A Hartman, Catharina; Salomaa, Veikko; Toniolo, Daniela; Perola, Markus; F Wilson, James; Schmidt, Helena; Hua Zhao, Jing; Lehtimäki, Terho; M van Duijn, Cornelia; Gudnason, Vilmundur; M Psaty, Bruce; Peters, Annette; Rettig, Rainer; James, Alan; Wouter Jukema, J; P Strachan, David; Palmas, Walter; Metspalu, Andres; Ingelsson, Erik; I Boomsma, Dorret; H Franco, Oscar; Bochud, Murielle; Newton-Cheh, Christopher; B Munroe, Patricia; Elliott, Paul; I Chasman, Daniel; Chakravarti, Aravinda; Knight, Joanne; P Morris, Andrew; Levy, Daniel; D Tobin, Martin; Snieder, Harold; J Caulfield, Mark; B Ehret, Georg; R Barnes, Michael; Tzoulaki, Ioanna; J Caulfield, Mark; Elliott, Paul

doi:10.1038/ng.3768

Public

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Published in Nature Genetics • Jan 30, 2017

Authors:

Helen R. Warren

Εvangelos Εvangelou

Claudia P. Cabrera

Abstract

Mark Caulfield, Paul Elliott and colleagues use data from the UK Biobank to perform genome-wide association analysis for blood pressure traits. They identify and validate 107 novel loci and highlight new biological pathways for potential therapeutic intervention for hypertension. Elevated blood pres...

Subject

Biobank

Blood pressure

Biology

Research Assistant

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