D-Cycloserine Augmentation of Exposure-Based Cognitive Behavior Therapy for Anxiety, Obsessive-Compulsive, and Posttraumatic Stress Disorders

Mataix‐Cols, David; Fernández de la Cruz, Lorena; Monzani, Benedetta; Rosenfield, David; Andersson, Erik; Pérez-Vigil, Ana; Frumento, Paolo; A. de Kleine, Rianne; Difede, JoAnn; W. Dunlop, Boadie; J. Farrell, Lara; Geller, Daniel; Gerardi, Maryrose; J. Guastella, Adam; G. Hofmann, Stefan; Hendriks, Gert‐Jan; G. Kushner, Matt; S. Lee, Francis; J. Lenze, Eric; A. Levinson, Cheri; McConnell, Harry; W. Otto, Michael; Plag, Jens; H. Pollack, Mark; J. Ressler, Kerry; L. Rodebaugh, Thomas; O. Rothbaum, Barbara; S. Scheeringa, Michael; Siewert-Siegmund, Anja; A. J. Smits, Jasper; A. Storch, Eric; Ströhle, Andreas; D. Tart, Candyce; F. Tolin, David; van Minnen, Agnes; M. Waters, Allison; F. Weems, Carl; Wilhelm, Sabine; Wyka, Katarzyna; Davis, Michael; Rück, Christian; Altemus, Margaret; L. Anderson, Page; Cukor, Judith; Finck, Claudia; R. Geffken, Gary; Golfels, Fabian; K. Goodman, Wayne; A. Gutner, Cassidy; Heyman, Isobel; Jovanović, Tanja; B. Lewin, Adam; P. H. McNamara, Joseph; K. Murphy, Tanya; D. Norrholm, Seth; Thuras, Paul

doi:10.1001/jamapsychiatry.2016.3955

Public

D-Cycloserine Augmentation of Exposure-Based Cognitive Behavior Therapy for Anxiety, Obsessive-Compulsive, and Posttraumatic Stress Disorders

Published in JAMA Psychiatry • Jan 25, 2017

Authors:

David Mataix‐Cols

Lorena Fernández de la Cruz

Benedetta Monzani

Abstract

Importance: Whether and under which conditions D-cycloserine (DCS) augments the effects of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders is unclear. Objective: To clarify whether DCS is superior to placebo in augmenting the effects of...

Subject

Agoraphobia

Generalized anxiety disorder

Anxiety

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