Sirtinol promotes PEPCK1 degradation and inhibits gluconeogenesis by inhibiting deacetylase SIRT2

Zhang, Mingming; Pan, Yida; Dorfman, Robert; Yin, Yuyao; Zhou, Qian; Huang, Shan; Liu, Jie; Zhao, Shimin

doi:10.1038/s41598-017-00035-9

Public

Sirtinol promotes PEPCK1 degradation and inhibits gluconeogenesis by inhibiting deacetylase SIRT2

Published in Scientific Reports • Jan 25, 2017

Authors:

Mingming Zhang

Yida Pan

Robert Dorfman

Abstract

Phosphoenolpyruvate carboxykinase 1 (PEPCK1) is the critical enzyme for gluconeogenesis and is linked with type II diabetes. Previous studies have found that SIRT2, a deacetylase, plays an important role in deacetylating PEPCK1 and little is known about the anti-diabetic activity of SIRT2 inhibitors...

Subject

SIRT2

Gluconeogenesis

Phosphoenolpyruvate carboxykinase

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