The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion

Lu, Chunwan; V. Paschall, Amy; Shi, Huidong; M. Savage, Natasha; L. Waller, Jennifer; E. Sabbatini, María; H. Oberlies, Nicholas; J. Pearce, Cedric; Liu, Kebin

doi:10.1093/jnci/djw283

Public

The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion

Published in JNCI Journal of the National Cancer Institute • Oct 27, 2016

Authors:

Chunwan Lu

Amy V. Paschall

Huidong Shi

Abstract

BACKGROUND: Pancreatic cancer is one of the cancers where anti-PD-L1/PD-1 immunotherapy has been unsuccessful. What confers pancreatic cancer resistance to checkpoint immunotherapy is unknown. The aim of this study is to elucidate the underlying mechanism of PD-L1 expression regulation in the contex...

Subject

Pancreatic cancer

Cancer research

H3K4me3

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