Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice

Gagnon, D.; Petryszyn, S.; G. Sanchez, M.; Bories, C.; M. Beaulieu, J.; De Koninck, Y.; Parent, A.; Parent, M.

doi:10.1038/srep41432

Public

Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice

Shared by NobleBlocks on Jan 27, 2017 • 12:00 AM UTC

Authors:

D. Gagnon

S. Petryszyn

M. G. Sanchez

Abstract

Abstract The loss of nigrostriatal dopamine neurons in Parkinson’s disease induces a reduction in the number of dendritic spines on medium spiny neurons (MSNs) of the striatum expressing D 1 or D 2 dopamine receptor. Consequences on MSNs expressing both receptors (D 1 /D 2 MSNs) are currently unknow...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!