Spherocytic shift of red blood cells during storage provides a quantitative whole cell–based marker of the storage lesion

Roussel, Camille; Dussiot, Michaël; Marin, Mickaël; Morel, Alexandre; Alioune Ndour, Papa; Duez, Julien; Le Van Kim, Caroline; Hermine, Olivier; Colin, Yves; Buffet, Pierre; Amireault, Pascal

doi:10.1111/trf.14015

Public

Spherocytic shift of red blood cells during storage provides a quantitative whole cell–based marker of the storage lesion

Published in Transfusion • Feb 1, 2017

Authors:

Camille Roussel

Michaël Dussiot

Mickaël Marin

Abstract

BACKGROUND: Storage lesion may explain the rapid clearance of up to 25% of transfused red blood cells (RBCs) in recipients. Several alterations affect stored RBC but a quantitative, whole cell-based predictor of transfusion yield is lacking. Because RBCs with reduced surface area are retained by the...

Subject

Echinocyte

Flow cytometry

Spleen

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