Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCK

Kumar Patel, Girijesh; Aslam Khan, Mohammad; Bhardwaj, Arun; K. Srivastava, Sanjeev; Zubair, Haseeb; C. Patton, Mary; Singh, Seema; Khushman, Moh’d; P. Singh, Ajay

doi:10.1038/bjc.2017.18

Public

Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCK

Published in British Journal of Cancer • Feb 1, 2017

Authors:

Girijesh Kumar Patel

Mohammad Aslam Khan

Arun Bhardwaj

Abstract

BACKGROUND: Chemoresistance is a significant clinical problem in pancreatic cancer (PC) and underlying molecular mechanisms still remain to be completely understood. Here we report a novel exosome-mediated mechanism of drug-induced acquired chemoresistance in PC cells. METHODS: Differential ultracen...

Subject

Downregulation and upregulation

Exosome

Microvesicles

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