Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Smith, Nikaïa; Pietrancosta, Nicolas; Davidson, Sophia; Dutrieux, Jacques; Chauveau, Lise; Cutolo, Pasquale; Dy, Michel; Scott‐Algara, Daniel; Manoury, Bénédicte; Zirafi, Onofrio; McCort‐Tranchepain, Isabelle; Durroux, Thierry; Bachelerie, Françoise; Schwartz, Olivier; Münch, Jan; Wack, Andreas; Nisole, Sébastien; Herbeuval, Jean‐Philippe

doi:10.1038/ncomms14253

Public

Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Published in Nature Communications • Feb 9, 2017

Authors:

Nikaïa Smith

Nicolas Pietrancosta

Sophia Davidson

Abstract

Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mou...

Subject

Plasmacytoid dendritic cell

Interferon

Innate immune system

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