Structure of the homodimeric androgen receptor ligand-binding domain

Nadal, Marta; Preković, Stefan; Gallastegui, Nerea; Helsen, Christine; Abella, Montserrat; Zielińska, Karolina; Gay, Marina; Vilaseca, Marta; Taulés, Marta; B. Houtsmuller, Adriaan; E. van Royen, Martin; Claessens, Frank; Fuentes‐Prior, Pablo; Estébanez‐Perpiñá, Eva

doi:10.1038/ncomms14388

Public

Structure of the homodimeric androgen receptor ligand-binding domain

Published in Nature Communications • Feb 6, 2017

Authors:

Marta Nadal

Stefan Preković

Nerea Gallastegui

Abstract

Abstract The androgen receptor (AR) plays a crucial role in normal physiology, development and metabolism as well as in the aetiology and treatment of diverse pathologies such as androgen insensitivity syndromes (AIS), male infertility and prostate cancer (PCa). Here we show that dimerization of AR ...

Subject

Androgen receptor

Coactivator

Nuclear receptor

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