PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression

Jiao, Shiping; Xia, Weiya; Yamaguchi, Hirohito; Wei, Yongkun; Chen, Mei‐Kuang; Hsu, Jung-Mao; L. Hsu, Jennifer; Yu, Wen-Hsuan; Du, Yi; Lee, Heng‐Huan; Li, Chia‐Wei; Chou, Chao‐Kai; Lim, Seung-Oe; Chang, Shih-Shin; K. Litton, Jennifer; Arun, Banu; N. Hortobágyi, Gabriel; Hung, Mien‐Chie

doi:10.1158/1078-0432.ccr-16-3215

Public

PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression

Published in Clinical Cancer Research • Feb 6, 2017

Authors:

Shiping Jiao

Weiya Xia

Hirohito Yamaguchi

Abstract

Abstract Purpose: To explore whether a cross-talk exists between PARP inhibition and PD-L1/PD-1 immune checkpoint axis, and determine whether blockade of PD-L1/PD-1 potentiates PARP inhibitor (PARPi) in tumor suppression. Experimental Design: Breast cancer cell lines, xenograft tumors, and syngeneic...

Subject

Immunosuppression

Cancer

Medicine

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