Favipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals concentrations lower than targeted

Huyen Tram Nguyen, Thi; Guedj, Jérémie; Anglaret, Xavier; Laouenan, Cédric; Madelain, Vincent; Taburet, Anne‐Marie; Baize, Sylvain; Sissoko, Daouda; Pastorino, Boris; Rodallec, Anne; Piorkowski, Géraldine; Carazo, Sara; N. Conde, Mamoudou; Gala, Jean‐Luc; Akoi Boré, Joseph; Carbonnelle, Caroline; Jacquot, Frédéric; Raoul, Hervé; Malvy, Denis; de Lamballerie, Xavier; Mentré, France; behalf of the JIKI study group, on

doi:10.1371/journal.pntd.0005389

Public

Favipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals concentrations lower than targeted

Published in PLoS neglected tropical diseases • Feb 23, 2017

Authors:

Thi Huyen Tram Nguyen

Jérémie Guedj

Xavier Anglaret

Abstract

BACKGROUND: In 2014-2015, we assessed favipiravir tolerance and efficacy in patients with Ebola virus (EBOV) disease (EVD) in Guinea (JIKI trial). Because the drug had never been used before for this indication and that high concentrations of the drugs were needed to achieve antiviral efficacy again...

Subject

Favipiravir

Pharmacokinetics

Ebola virus

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