Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC-1ɑ-SOD2-mediated regulation of mitochondrial function

Ding, Yong; Yang, Hongmei; Wang, Yucai; Chen, Jun; Ji, Zhenwei; Sun, Honghui

doi:10.7150/ijbs.17053

Public

Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC-1ɑ-SOD2-mediated regulation of mitochondrial function

Published in International Journal of Biological Sciences • Jan 1, 2017

Authors:

Yong Ding

Hongmei Yang

Yucai Wang

Abstract

Osteogenic differentiation is crucial for the maintenance of bone homeostasis. Sirtuin 3 (SIRT3), a member of sirtuins family, functions as a critical deacetylase that regulates many key proteins. In the current study, we aimed to clarify the role of SIRT3 in osteogenic differentiation and the possi...

Subject

SIRT3

Gene knockdown

SOD2

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