Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing

Li, Ji; J. Stagg, Nicola; Johnston, Jennifer; J. Harris, Michael; A. Menzies, Sam; DiCara, Danielle; Clark, Vanessa; Hristopoulos, Maria; Cook, Ryan; Slaga, Dionysos; Nakamura, Rin; Luke, McCarty; Sukumaran, Siddharth; Luis, Elizabeth; Ye, Zhengmao; D. Wu, Thomas; Sumiyoshi, Teiko; M. Danilenko, Dimitry; Y. Lee, Genee; Tótpál, Klára; Ellerman, Diego; Hötzel, Isidro; R. James, John; T. Junttila, Teemu

doi:10.1016/j.ccell.2017.02.001

Public

Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing

Published in Cancer Cell • Mar 1, 2017

Authors:

Ji Li

Nicola J. Stagg

Jennifer Johnston

Abstract

The anti-FcRH5/CD3 T cell-dependent bispecific antibody (TDB) targets the B cell lineage marker FcRH5 expressed in multiple myeloma (MM) tumor cells. We demonstrate that TDBs trigger T cell receptor activation by inducing target clustering and exclusion of CD45 phosphatase from the synapse. The dime...

Subject

CD3

Immunological synapse

T cell

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