The Transient Receptor Potential Melastatin 7 Channel Regulates Pancreatic Cancer Cell Invasion through the Hsp90α/uPA/MMP2 pathway

Rybarczyk, Pierre; Vanlaeys, Alison; Brassart, Bertrand; Dhennin‐Duthille, Isabelle; Chatelain, Denis; Sevestre, Henri; Ouadid‐Ahidouch, Halima; Gautier, Mathieu

doi:10.1016/j.neo.2017.01.004

Public

The Transient Receptor Potential Melastatin 7 Channel Regulates Pancreatic Cancer Cell Invasion through the Hsp90α/uPA/MMP2 pathway

Published in Neoplasia • Mar 8, 2017

Authors:

Pierre Rybarczyk

Alison Vanlaeys

Bertrand Brassart

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a very poor prognosis. There is an urgent need to better understand the molecular mechanisms that regulate PDAC cell aggressiveness. The transient receptor potential melastatin 7 (TRPM7) is a nonselective cationic channel that ...

Subject

TRPM7

Cancer research

Urokinase receptor

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!