Cell-Free DNA and Active Rejection in Kidney Allografts

D. Bloom, Roy; S. Bromberg, Jonathan; D. Poggio, Emilio; Bunnapradist, Suphamai; Langone, Anthony; Sood, Puneet; J. Matas, Arthur; Mehta, Shikha; B. Mannon, Roslyn; Sharfuddin, Asif; Fischbach, Bernard; Narayanan, Mohanram; C. Jordan, Stanley; J. Cohen, David; R. Weir, Matthew; Hiller, D.; Prasad, Preethi; Woodward, R.; Grs̆ković, Marica; J. Sninsky, John; Yee, James; C. Brennan, Daniel; the Circulating Donor-Derived Cell-Free DNA in Blood for Diagnosing Active Rejection in Kidney Transplant Recipients (DART) Study Investigators, for

doi:10.1681/asn.2016091034

Public

Cell-Free DNA and Active Rejection in Kidney Allografts

Published in Journal of the American Society of Nephrology • Mar 9, 2017

Authors:

Roy D. Bloom

Jonathan S. Bromberg

Emilio D. Poggio

Abstract

Histologic analysis of the allograft biopsy specimen is the standard method used to differentiate rejection from other injury in kidney transplants. Donor-derived cell-free DNA (dd-cfDNA) is a noninvasive test of allograft injury that may enable more frequent, quantitative, and safer assessment of a...

Subject

Medicine

Biopsy

Receiver operating characteristic

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