Extensive translation of circular RNAs driven by N6-methyladenosine

Yang, Yun; Fan, Xiaojuan; Mao, Miaowei; Song, Xiaowei; Wu, Ping; Zhang, Yang; Jin, Yongfeng; Yang, Yi; Chen, Ling‐Ling; Wang, Yang; C. L. Wong, Catherine; Xiao, Xinshu; Wang, Zefeng

doi:10.1038/cr.2017.31

Public

Extensive translation of circular RNAs driven by N6-methyladenosine

Published in Cell Research • Mar 10, 2017

Authors:

Yun Yang

Xiaojuan Fan

Miaowei Mao

Abstract

Extensive pre-mRNA back-splicing generates numerous circular RNAs (circRNAs) in human transcriptome. However, the biological functions of these circRNAs remain largely unclear. Here we report that N 6 -methyladenosine (m 6 A), the most abundant base modification of RNA, promotes efficient initiation...

Subject

Biology

N6-Methyladenosine

Translation (biology)

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