Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance

Roh, Whijae; Chen, Pei-Ling; Reuben, Alexandre; N. Spencer, Christine; A. Prieto, Peter; P. Miller, John; Gopalakrishnan, Vancheswaran; Wang, Feng; A. Cooper, Zachary; M. Reddy, Sangeetha; Gumbs, Curtis; Little, Latasha; Chang, Qing; Chen, Wei-Shen; Wani, Khalida; Petaccia de Macêdo, Mariana; Chen, Eveline; L. Austin-Breneman, Jacob; Jiang, Hong; Roszik, Jason; T. Tetzlaff, Michael; A. Davies, Michael; E. Gershenwald, Jeffrey; A. Tawbi, Hussein; J. Lazar, Alexander; Hwu, Patrick; Hwu, Wen-Jen; Diab, Adi; C. Glitza, Isabella; P. Patel, Sapna; E. Woodman, Scott; N. Amaria, Rodabe; G. Prieto, Víctor; Hu, Jianhua; Sharma, Padmanee; P. Allison, James; Chin, Lynda; Zhang, Jianhua; A. Wargo, Jennifer; Andrew Futreal, P.

doi:10.1126/scitranslmed.aah3560

Public

Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance

Published in Science Translational Medicine • Mar 1, 2017

Authors:

Whijae Roh

Pei-Ling Chen

Alexandre Reuben

Abstract

Immune checkpoint blockade produces clinical benefit in many patients. However, better biomarkers of response are still needed, and mechanisms of resistance remain incompletely understood. To address this, we recently studied a cohort of melanoma patients treated with sequential checkpoint blockade ...

Subject

Blockade

Immune checkpoint

CTLA-4

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