Establishment of an AUC <sub>0–24</sub> Threshold for Nephrotoxicity Is a Step towards Individualized Vancomycin Dosing for Methicillin-Resistant Staphylococcus aureus Bacteremia

Chavada, Ruchir; Ghosh, Nabanita; Sandaradura, Indy; Maley, Michael; J. van Hal, Sebastiaan

doi:10.1128/aac.02535-16

Public

Establishment of an AUC 0–24 Threshold for Nephrotoxicity Is a Step towards Individualized Vancomycin Dosing for Methicillin-Resistant Staphylococcus aureus Bacteremia

Published in Antimicrobial Agents and Chemotherapy • Feb 28, 2017

Authors:

Ruchir Chavada

Nabanita Ghosh

Indy Sandaradura

Abstract

ABSTRACT Unlike vancomycin trough concentrations, data on the utility of vancomycin pharmacokinetic (PK) parameters, namely, the area under the concentration-time curve from 0 to 24 h (AUC 0–24 ), in predicting acute kidney injury (AKI) are limited. Our aim was to investigate this relationship in pa...

Subject

Dosing

Nephrotoxicity

Vancomycin

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