Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway

Wang, Tingting; Zhao, Yongliang; Peng, Liu‐sheng; Chen, Na; Chen, Weisan; Lv, Yi-pin; Mao, Fangyuan; Zhang, Jinyu; Cheng, Ping; Teng, Yong‐sheng; Fu, Xiaolong; Yu, Pei-wu; Guo, Gang; Luo, Ping; Zhuang, Yuan; Zou, Quanming

doi:10.1136/gutjnl-2016-313075

Public

Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway

Published in Gut • Mar 8, 2017

Authors:

Tingting Wang

Yongliang Zhao

Liu‐sheng Peng

Abstract

Objective Neutrophils are prominent components of solid tumours and exhibit distinct phenotypes in different tumour microenvironments. However, the nature, regulation, function and clinical relevance of neutrophils in human gastric cancer (GC) are presently unknown. Design Flow cytometry analyses we...

Subject

STAT protein

Biology

Immune system

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