Editing VEGFR2 Blocks VEGF-Induced Activation of Akt and Tube Formation

Huang, Xionggao; Zhou, Guohong; Wu, Wenyi; Ma, Gaoen; A. D'Amore, Patrìcia; Mukai, Shizuo; Lei, Hetian

doi:10.1167/iovs.16-20537

Public

Editing VEGFR2 Blocks VEGF-Induced Activation of Akt and Tube Formation

Published in Investigative Ophthalmology & Visual Science • Feb 27, 2017

Authors:

Xionggao Huang

Guohong Zhou

Wenyi Wu

Abstract

Purpose: Vascular endothelial growth factor receptor 2 (VEGFR2) plays a key role in VEGF-induced angiogenesis. The goal of this project was to test the hypothesis that editing genomic VEGFR2 loci using the technology of clustered regularly interspaced palindromic repeats (CRISPR)-associated DNA endo...

Subject

Sanger sequencing

Molecular biology

Oncostatin M

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