Nanodiamond as a Vector for siRNA Delivery to Ewing Sarcoma Cells

Alhaddad, Anna; Adam, Marie‐Pierre; Botsoa, Jacques; Dantelle, Géraldine; Perruchas, Sandrine; Gacoin, Thierry; Mansuy, Christelle; Lavielle, Solange; Malvy, Claude; Treussart, François; Bertrand, Jean‐Rémi

doi:10.1002/smll.201101193

Public

Nanodiamond as a Vector for siRNA Delivery to Ewing Sarcoma Cells

Published in Small • Sep 12, 2011

Authors:

Anna Alhaddad

Marie‐Pierre Adam

Jacques Botsoa

Abstract

The ability of diamond nanoparticles (nanodiamonds, NDs) to deliver small interfering RNA (siRNA) into Ewing sarcoma cells is investigated with a view to the possibility of in-vivo anticancer nucleic-acid drug delivery. siRNA is adsorbed onto NDs that are coated with cationic polymer. Cell uptake of...

Subject

Nanodiamond

Internalization

Nucleic acid

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