Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria

Lennartz, F.; Adams, Yvonne; Bengtsson, Anja; W. Olsen, Rebecca; Turner, Louise; Tuikue Ndam, Nicaise; Ecklu-Mensah, Gertrude; Moussiliou, Azizath; F. Ofori, Michael; Gamain, Benoît; Lusingu, John; E. V. Petersen, Jens; W. Wang, Christian; Nunes-Silva, Sofia; S. Jespersen, Jakob; K. Lau, Clinton; G. Theander, Thor; Lavstsen, Thomas; Hviid, Lars; K. Higgins, Matthew; T. R. Jensen, Anja

doi:10.1016/j.chom.2017.02.009

Public

Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria

Published in Cell Host & Microbe • Mar 1, 2017

Authors:

F. Lennartz

Yvonne Adams

Anja Bengtsson

Abstract

Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display parasite proteins of the PfEMP1 family that bind various endothelial receptors. Despite the importance of cerebral malaria, a ...

Subject

Cerebral Malaria

Biology

Plasmodium falciparum

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