Regulatory T cells promote myelin regeneration in the central nervous system

Dombrowski, Yvonne; O’Hagan, Thomas; Dittmer, Marie; Peñalva, Rosana; R. Mayoral, Sonia; Bankhead, Peter; Fleville, Samara; Eleftheriadis, George; Zhao, Chao; Naughton, Michelle; Hassan, Rachel; Moffat, Jill; Falconer, John; Boyd, Amanda; Hamilton, Peter; V. Allen, Ingrid; Kissenpfennig, Adrien; N Moynagh, Paul; Evergren, Emma; Perbal, Bernard; Williams, Anna; J. Ingram, Rebecca; R. Chan, Jonah; J.M. Franklin, Robin; Fitzgerald, Denise

doi:10.1038/nn.4528

Public

Regulatory T cells promote myelin regeneration in the central nervous system

Published in Nature Neuroscience • Mar 13, 2017

Authors:

Yvonne Dombrowski

Thomas O’Hagan

Marie Dittmer

Abstract

Regeneration of myelin is a dynamic, yet enigmatic process. Dombrowski et al. uncover a central role for regulatory T (Treg) cells in driving oligodendrocyte differentiation, in part via CCN3, a novel factor in Treg function and oligodendrocyte biology. This identifies Treg cells as key cellular pla...

Subject

Remyelination

Oligodendrocyte

Biology

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