Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals

P. Schultz, Aaron; P. Chhatwal, Jasmeer; Hedden, Trey; C. Mormino, Elizabeth; Hanseeuw, Bernard; Sepulcre, Jorge; Huijbers, Willem; R. LaPoint, Molly; F. Buckley, Rachel; A. Johnson, Keith; A. Sperling, Reisa

doi:10.1523/jneurosci.3263-16.2017

Public

Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals

Published in Journal of Neuroscience • Mar 17, 2017

Authors:

Aaron P. Schultz

Jasmeer P. Chhatwal

Trey Hedden

Abstract

Alzheimer's disease (AD) is characterized by two hallmark molecular pathologies: amyloid aβ 1–42 and Tau neurofibrillary tangles. To date, studies of functional connectivity MRI (fcMRI) in individuals with preclinical AD have relied on associations with in vivo measures of amyloid pathology. With th...

Subject

Default mode network

Neuroscience

Salience (neuroscience)

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