Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics

Boeynaems, Steven; Bogaert, Elke; Kovács, Dénes; Konijnenberg, Albert; Timmerman, Evy; N. Volkov, Alexander; Guharoy, Mainak; De Decker, Mathias; Jaspers, Tom; H. Ryan, Veronica; M. Janke, Abigail; Baatsen, Pieter; Vercruysse, Thomas; Kolaitis, Regina‐Maria; Daelemans, Dirk; Paul Taylor, J.; Kedersha, Nancy; Anderson, Paul; Impens, Francis; Sobott, Frank; Schymkowitz, Joost; Rousseau, Frédéric; L. Fawzi, Nicolas; Robberecht, Wim; Van Damme, Philip; Tompa, Péter; Van Den Bosch, Ludo

doi:10.1016/j.molcel.2017.02.013

Public

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics

Published in Molecular Cell • Mar 1, 2017

Authors:

Steven Boeynaems

Elke Bogaert

Dénes Kovács

Abstract

Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in the formation of multiple membrane-less organelles involved in RNA metabolism, including stress granules. Defects in stress granule homeostasis constitute a cornerstone of ALS/FTLD pathogenesis. Polar residues (...

Subject

Stress granule

Biology

RNA

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