Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in <i>Plasmodium falciparum</i> egress.

In the asexual blood stages of malarial infection, merozoites invade erythrocytes and replicate within a parasitophorous vacuole to form daughter cells that eventually exit (egress) by sequential rupture of the vacuole and erythrocyte membranes. The current model is that PKG, a malarial cGMP-depende... View More