Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5

Obayashi, E.; E. Luna, Rafael; Nagata, Takashi; Martín-Marcos, Pilar; Hiraishi, Hiroyuki; Ranjit Singh, Chingakham; P. Erzberger, Jan; Zhang, Fan; Arthanari, Haribabu; Morris, Jacob; Pellarin, Riccardo; Moore, Chelsea; Harmon, Ian; Papadopoulos, Evangelos; Yoshida, Hisashi; L. Nasr, Mahmoud; Unzai, Satoru; Thompson, Brytteny; Aube, Eric; Hustak, Samantha; Stengel, Florian; Dagraca, Eddie; Ananbandam, Asokan; Gao, Philip; Urano, Takeshi; G. Hinnebusch, Alan; Wagner, Gerhard; Asano, Katsura

doi:10.1016/j.celrep.2017.02.052

Public

Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5

Published in Cell Reports • Mar 1, 2017

Authors:

E. Obayashi

Rafael E. Luna

Takashi Nagata

Abstract

During eukaryotic translation initiation, eIF3 binds the solvent-accessible side of the 40S ribosome and recruits the gate-keeper protein eIF1 and eIF5 to the decoding center. This is largely mediated by the N-terminal domain (NTD) of eIF3c, which can be divided into three parts: 3c0, 3c1, and 3c2. ...

Subject

Messenger RNA

Internal ribosome entry site

Ribosome

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