Adaptative evolution of the<i>Vkorc1</i>gene in<i>Mus musculus domesticus</i>is influenced by the selective pressure of anticoagulant rodenticides

Goulois, Joffrey; Lambert, Véronique; Legros, Lionel; Benoît, Etienne; Lattard, Virginie

doi:10.1002/ece3.2829

Public

Adaptative evolution of theVkorc1gene inMus musculus domesticusis influenced by the selective pressure of anticoagulant rodenticides

Published in Ecology and Evolution • Mar 21, 2017

Authors:

Joffrey Goulois

Véronique Lambert

Lionel Legros

Abstract

Abstract Anticoagulant rodenticides are commonly used to control rodent pests worldwide. They specifically inhibit the vitamin K epoxide reductase ( VKORC 1), which is an enzyme encoded by the Vkorc1 gene, involved in the recycling of vitamin K. Therefore, they prevent blood clotting. Numerous mutat...

Subject

Vitamin K epoxide reductase

VKORC1

Biology

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