Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS

Gianfrancesco, Milena; Stridh, Pernilla; Rhead, Brooke; Shao, Xiaorong; Xu, Edison; Graves, Jennifer; Chitnis, Tanuja; Waldman, Amy; Lotze, Timothy; Schreiner, Teri; Belman, Anita; Greenberg, Benjamin; Weinstock‐Guttman, Bianca; Aaen, Gregory; Mendelt Tillema, Jan; Hart, Janace; J. Caillier, Stacy; Ness, Jayne; Harris, Yolanda; Rubin, Jennifer; Candee, Meghan; Krupp, Lauren; Gorman, Mark; Benson, Lina; Rodriguez, Moses; Mar, Soe; Kahn, Ilana; Rose, John; Roalstad, Shelly; Charles Casper, T.; Shen, Ling; Quach, Hong; Quach, Diana; Hillert, Jan; Bäärnhielm, Maria; Karin Hedström, Anna; Olsson, Tomas; Kockum, Ingrid; Alfredsson, Lars; Metayer, Catherine; Schaefer, Catherine; F. Barcellos, Lisa; Waubant, Emmanuelle; Graves, Jennifer; Chitnis, Tanuja; Waldman, Amy; Loetze, Timothy; Schreiner, Teri; Belman, Anita; Greenberg, Benjamin; Weinstock‐Guttman, Bianca; Aaen, Gregory; Mendelt Tillema, Jan; Hart, Janace; J. Caillier, Stacy; Ness, Jayne; Harris, Yolanda; Rubin, Jennifer; Candee, Meghan; Krupp, Lauren; Gorman, Mark; Benson, Lina; Rodriguez, Moses; Mar, Soe; Kahn, Ilana; Rose, John; Roalstad, Shelly; Charles Casper, T.; Waubant, Emmanuelle

doi:10.1212/wnl.0000000000003849

Public

Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS

Published in Neurology • Mar 30, 2017

Authors:

Milena Gianfrancesco

Pernilla Stridh

Brooke Rhead

Abstract

Objective: To utilize Mendelian randomization to estimate the causal association between low serum vitamin D concentrations, increased body mass index (BMI), and pediatric-onset multiple sclerosis (MS) using genetic risk scores (GRS). Methods: We constructed an instrumental variable for vitamin D (v...

Subject

Medicine

Pediatrics

Age of onset

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