HMGB1 induces lung fibroblast to myofibroblast differentiation through NF-κB-mediated TGF-β1 release

Wang, Qiong; Wang, Jun; Wang, Junfang; Hong, Shanchao; Han, Feifei; Chen, Jingyu; Chen, Guoqian

doi:10.3892/mmr.2017.6364

Public

HMGB1 induces lung fibroblast to myofibroblast differentiation through NF-κB-mediated TGF-β1 release

Published in Molecular Medicine Reports • Mar 23, 2017

Authors:

Qiong Wang

Jun Wang

Junfang Wang

Abstract

The proinflammatory factor high‑mobility group box protein 1 (HMGB1) has been implicated in the pathogenesis of lung fibrosis; however, the role of HMGB1 in lung fibrosis remains unclear. It has previously been reported that nuclear factor (NF)‑κB and transforming growth factor (TGF)‑β1 may be invol...

Subject

Myofibroblast

HMGB1

Fibroblast

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